PhD Student postitions in Protease Research (GRK 2606 „ProtPath“) in Lörrach

Universitätsklinikum Freiburg


The Institute of Molecular Medicine and Cell Research is looking for PhD Student postitions in Protease Research (GRK 2606 „ProtPath“) The Research Training Group 2606 entitled Understanding Protease Functions in Cellular Pathways through Discovery and Analysis of Protease Substrates (ProtPath) is a German Research Foundation (DFG)-funded doctoral program for research concerning proteases, their substrates and their functions in biology and medicine. Biochemistry, cell biology, genetics, and proteomics are the key methodologies of our research endeavor. We have formed an excellent scientific network integrating projects located on internationally renowned research institutes and departments of Freiburg University and its Medical Center. Our mission is to support the fully funded PhD work of early stage researchers that have completed their undergraduate training in a life science subject. We aim to develop motivated, responsible, and scientifically independent researchers fit for the postdoctoral job market in academia, biotech, and industry. The PI Klaus-Peter Knobeloch has one open position in a project investigating a subgroup of deubiquitinating enzymes. CrispR/Cas9 mediated genome editing, gene knockout mice and proteome analysis will be used to dissect functions of the closely related ubiquitin specific proteases USP15, USP11 and USP4. These related USPs represent potential therapeutic target molecules within the context of Parkinson’s disease, neuroinflammation, metabolic disorders, and cancer. We offer a straightforward project which is based on extensive unpublished preliminary data and provide excellent working conditions in a highly motivated environment where hard work does not exclude fun. Exemplary for our work are the following publications: Papain-like protease regulates SARS-CoV-2 viral spread and innate immunity. Shin D et al., Nature 2020. PMID: 32726803. Structural basis of the specificity of USP18 toward ISG15. Basters et al. Nat Struct Mol Biol. 2017. PMID: 28165509. The ubiquitin-specific protease USP8 is critical for the development and homeostasis of T cells. Dufner et al. Nature Immunology 2015. PMID: 26214742. We offer a 3-year contract duration (Salary scheme E13 TV-L; 65 %). The position is available as soon as possible. Check for individual project description, how-to-apply, and learn more about GRK 2606 on: Website

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